East San Diego Homes with Mixed Use Subtype

Welcome to East San Diego, a vibrant and diverse community nestled in the heart of California's sunny San Diego County. Known for its eclectic blend of urban living and suburban charm, East San Diego offers a unique lifestyle that caters to both families and young professionals alike. With its picturesque neighborhoods, stunning parks, and close proximity to downtown San Diego, this area is perfect for those seeking a lively yet relaxed atmosphere.

One of the standout features of East San Diego is its mixed-use properties, which beautifully blend residential and commercial spaces. These homes with a mixed-use subtype provide a perfect opportunity for homeowners and entrepreneurs to live and work in the same vibrant environment. Imagine waking up in your stylish loft, stepping out to grab a coffee from your favorite local café, and then heading down to your own boutique or office, all within a short stroll from your front door.

The mixed-use developments in East San Diego not only encourage a sense of community but also foster a dynamic lifestyle where convenience and creativity thrive. Residents can enjoy an array of amenities, including shops, restaurants, and recreational spaces, all designed to enhance the quality of life.

Whether you’re looking for a cozy apartment or a spacious townhouse, East San Diego’s mixed-use homes offer countless possibilities for living and working in harmony. Embrace the opportunity to be part of this thriving community where the best of urban and suburban life come together, making East San Diego a truly exceptional place to call home.

Newest East San Diego Homes with Mixed Use Subtype

$1,799,000

260022112SD MLS ⋅ Active Status

Pleased to present 4073 Chamoune Avenue, a well-maintained 5-unit multifamily investment opportunity located in San Diego’s established City Heights neighborhood. Built in 1988, the property consists of five 3-bedroom, 2-bathroom units, totaling 15 bedrooms and 10 bathrooms. The property offers seven enclosed garage parking spaces plus one additional uncovered space, providing a strong parking ratio for the asset. Additional features include alley access, electronic security gates, and an onsite laundry facility.

4073 Chamoune Ave, East San Diego

$2,800,000

260021529SD MLS ⋅ Active Status

Exceptional 17-unit gated multifamily investment opportunity in City Heights. Currently operating as a 62+ community, the property offers established operations, desirable amenities, and significant value-add potential. All units feature air conditioning, with an elevator and on-site laundry. Several units have been renovated, while the remaining units provide an opportunity for further upgrades and rental growth. The property is also eligible for the Complete Communities Housing Solutions program due to its location within a Sustainable Development Area (SDA), enhancing the property's underlying land value and providing significant long-term development upside. Ideally located in City Heights near Teralta Park, the property provides convenient access to Interstate 15 and is centrally positioned for access to Downtown San Diego and surrounding neighborhoods. Residents enjoy close proximity to shopping, dining, parks, public transportation, and a variety of everyday services.

4226 41st Street, East San Diego

$3,100,000

260019642SD MLS ⋅ Active Status

4022 42nd Street presents an 11-unit multifamily investment opportunity in San Diego’s City Heights neighborhood. The property features six one-bedroom/one-bath units and five two-bedroom/one-bath units, including two recently added ADUs. Totaling approximately 7,354 rentable square feet on a 7,021-square-foot lot, the gated property offers on-site parking and community laundry. Conveniently located near shopping, dining, public transportation and major freeways, the property provides access to Downtown San Diego, North Park and surrounding employment centers. Buyer to verify all property information, including square footage, unit count, permits and financial data.

4022 42nd Street, East San Diego

$4,100,000

260019277SD MLS ⋅ Active Status

We are pleased to present 5260-62 Rex Avenue, a 13-unit property located in the City Heights neighborhood of San Diego, CA situated on two adjacent lots totaling 0.23 acres. The property is comprised of thirteen (13) two-bedroom / two-bathroom units and has 11 single car garages which presents an opportunity for ADU conversion. City Heights is known for its cultural diversity, locally owned businesses, and international cuisine. The residents are centrally located in San Diego near ground zero of City Heights new urban core. Residents enjoy quick access to El Cajon Boulevard and Interstate-15. This property is situated in a transit-oriented neighborhood with many public transportation options nearby. Located along major east-west/north-south thoroughfares and transit hubs provides residents ease of access to jobs, education, public facilities, parks and community recreation. The property boasts a walk score of 93 on Walkscore.com’s 100-point scale and is considered “Very Walkable” as daily errands do not require a car and countless retailers, restaurants, and services are also nearby. This property provides an investor the opportunity to purchase a quality value-add asset in a high barrier to entry market. The property has undergone consistent renovations throughout the units demonstrating pride of ownership and provides a prime opportunity to continue improvement through the potential development of additional units.

5260 Rex Ave, East San Diego

$6,995,000

260019215SD MLS ⋅ Active Status

This is an extensively renovated (2020) and well-maintained 22-unit apartment community in the City Heights neighborhood of San Diego. This property has a fantastic unit mix: eighteen (18) 2Bdrm/2Bath with in-unit laundry and four (4) 1Bdrm/1Bath units. The property has ample onsite parking (28 spaces) and is situated in a predominantly single-family neighborhood near transit, local freeways and shopping. This represents an opportunity to acquire a fully renovated asset with strong in-place rents with additional upside in one of San Diego's best-performing submarkets. Two separate parcels (454-332-27-00 & 454-332-01-00)

3423 Marlborough Ave, East San Diego

$1,600,000

260017277SD MLS ⋅ Active Status

Attention Investors and Developers! This is an incredible opportunity to own an income property with the potential to add six additional units with approved zoning (see documents), expanding the current six-unit property to a possible twelve units. Situated on just under half an acre at the end of a quiet cul-de-sac, this property offers both privacy and convenient access to major commuter routes. With six existing units—three 2-bedroom, 1-bath units and two 1-bedroom, 1-bath units and a studio—the investment potential is outstanding. The property features two separate buildings, with four units in the main building and two units in the second building, plus plenty of parking for tenants, both in the front and back. Built in 1958, this property presents a rare chance for investors or developers to significantly increase rental income and maximize the value of the lot. Opportunities like this are hard to find—don’t miss out.

2499 Tuberose St, East San Diego

$8,995,000

260007745SD MLS ⋅ Active Status

Rare investment opportunity featuring a $48,000/month NNN master lease with House of Metamorphosis, a well-established nonprofit operator with approximately 50 years in business, delivering stable, predictable income with minimal landlord responsibility. The property consists of 26 units, each with a private bathroom, purposefully designed for supervised residential care. The 8,450 SF building offers an average unit size of approximately 325 SF, maximizing income efficiency. Situated on a 7,000 SF lot with motel zoning, the property presents limited land value contribution; however, the zoning carries significant embedded entitlement value for SRO and behavioral health uses—an increasingly scarce and difficult-to-replicate asset class in San Diego. Investors are presented with a dual-path opportunity: continue operating with a reputable, long-term tenant under a true NNN structure, or reposition the asset for alternative residential or lodging uses, leveraging the existing 26-unit configuration and flexible zoning.

4017 42nd St, East San Diego

$2,170,000

260006407SD MLS ⋅ Active Status

Excellent opportunity to own an 8-unit property well located in San Diego. Four units feature 2 bedrooms and 1 bathroom, while the remaining four units offer 1 bedroom and 1 bathroom. Each unit includes a designated parking space, and the property features an on-site laundry room.The property is conveniently situated near schools, shopping, dining, and major freeways, offering strong rental appeal.Property is currently tenant-occupied. Do not disturb occupants. Buyer to verify all information.A great opportunity to secure a high-demand investment property don't miss this chance.

3805 Winona Ave, East San Diego

$2,275,000

250042932SD MLS ⋅ Active Status

4062 49th Street is a 9-unit complex in City Heights with plenty of parking. The 5,190 square foot building built in 1968 is situated on a 5,739 square foot lot. There are nine 1 Bedroom / 1 Bathroom units. All units have been completely remodeled in 2025. There was a new roof installed as well as stucco repair, exterior repaint, new security doors, and water proofing of the balconies. All unit interiors feature new canned lighting, window coverings and vinyl plank flooring with new baseboards. All units have new appliances and electric wall heaters powered by new sub panels. Plumbing was replaced with copper and ABS as needed. The kitchens and bathrooms feature new cabinets, fixtures, hardware, and quartz countertops. There is an onsite laundry facility that has been expanded and has new machines. The property is located in City Heights, close to the transit and shopping off El Cajon Blvd.

4062 49th Street, East San Diego

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Based on information from California Regional Multiple Listing Service, Inc. as of . This information is for your personal, non-commercial use and may not be used for any purpose other than to identify prospective properties you may be interested in purchasing. Display of MLS data is usually deemed reliable but is NOT guaranteed accurate by the MLS. Buyers are responsible for verifying the accuracy of all information and should investigate the data themselves or retain appropriate professionals. Information from sources other than the Listing Agent may have been included in the MLS data. Unless otherwise specified in writing, Broker/Agent has not and will not verify any information obtained from other sources. The Broker/Agent providing the information contained herein may or may not have been the Listing and/or Selling Agent.